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Review
10.1517/14728222.10.1.87 © 2006 Ashley Publications ISSN 1472-8222 87 Ashley Publications
www.ashley-pub.com

From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer

Bharat B Aggarwal?, Haruyo Ichikawa, Prachi Garodia, Priya Weerasinghe, Gautam Sethi, Indra D Bhatt, Manoj K Pandey, Shishir Shishodia & Muraleedharan G Nair
?The University of Texas, MD Anderson Cancer Center, Cytokine Research Laboratory, Department of Experimental Therapeutics, Box 143, 1515 Holcombe Boulevard, Houston, Texas 77030, USA,

Cancer is a hyperproliferative disorder that involves transformation, dysregulation of apoptosis, proliferation, invasion, angiogenesis and metastasis. Extensive research during the last 30 years has revealed much about the biology of cancer. Drugs used to treat most cancers are those that can block cell signalling, including growth factor signalling (e.g., epidermal growth factor); prostaglandin production (e.g., COX-2); inflammation (e.g., inflammatory cytokines: NF-?B, TNF, IL-1, IL-6, chemokines); drug resistance gene products (e.g., multi-drug resistance); cell cycle proteins (e.g., cyclin D1 and cyclin E); angiogenesis (e.g., vascular endothelial growth factor); invasion (e.g., matrix metalloproteinases); antiapoptosis (e.g., bcl-2, bcl-XL, XIAP, survivin, FLIP); and cellular proliferation (e.g., c-myc, AP-1, growth factors). Numerous reports have suggested that Ayurvedic plants and their components mediate their effects by modulating several of these recently identified therapeutic targets. However, Ayurvedic medicine requires rediscovery in light of our current knowledge of allopathic (modern) medicine. The focus of this review is to elucidate the Ayurvedic concept of cancer, including its classification, causes, pathogenesis and prevention; surgical removal of tumours; herbal remedies; dietary modifications; and spiritual treatments.

Keywords: apoptosis, Ayurvedic medicine, cancer, inflammation, metastasis Expert Opin. Ther. Targets (2006) 10(1):87-118
PMID: 16441231

"From Ancient Medicine to Modern Medicine: Ayurvedic Concepts of Health and its role in Inflammation and Cancer"

J Soc Integr Oncol. 2007 Winter;5(1):25-37
Invited Review for the Journal of the Society for Integrative Oncology (winter issue) Prachi Garodia, Haruyo Ichikawa, Nikita Malani, Gautam Sethi and Bharat B Aggarwal?

Abstract
Recent statistics indicate that overall cancer incidence in the United States, in spite of billions of dollars spent on research each year, has not changed significantly in the last half century. Cancers of the prostate, breast, lung and colon, while most common in the Western world, are least common in the Eastern world. Allopathic medicine commonly practiced currently is only one hundred years old. Although traditional medicine has been around for thousands of years, no integration exists between it and allopathic medicine. Ayurveda, the science of long life and one of the most ancient medical systems still practiced on the Indian subcontinent, can be used in combination with modern medicine to provide better treatment of cancer. This review focuses on the Ayurvedic concept of the causes of cancer, its linkage with inflammation, its diagnosis, prevention and treatment. How Ayurvedic medicine can be integrated with allopathic medicine is also discussed in this review.
PMID: 17309811