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Ayurvedicure is
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naturally and providing the healing tools in their own hands.
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Review
10.1517/14728222.10.1.87 © 2006 Ashley Publications ISSN 1472-8222 87 Ashley
Publications
www.ashley-pub.com
From traditional Ayurvedic medicine
to modern medicine: identification
of therapeutic targets for suppression of inflammation and cancer
Bharat B Aggarwal?, Haruyo Ichikawa, Prachi Garodia, Priya Weerasinghe, Gautam
Sethi, Indra D Bhatt, Manoj K Pandey, Shishir Shishodia & Muraleedharan G
Nair
?The University of Texas, MD Anderson Cancer Center, Cytokine Research
Laboratory, Department of Experimental Therapeutics, Box 143, 1515 Holcombe
Boulevard, Houston, Texas 77030, USA,
Cancer is a hyperproliferative disorder that involves transformation,
dysregulation of apoptosis, proliferation, invasion, angiogenesis and
metastasis. Extensive research during the last 30 years has revealed much about
the biology of cancer. Drugs used to treat most cancers are those that can
block cell signalling, including growth factor signalling (e.g., epidermal
growth factor); prostaglandin production (e.g., COX-2); inflammation (e.g.,
inflammatory cytokines: NF-?B, TNF, IL-1, IL-6, chemokines); drug resistance
gene products (e.g., multi-drug resistance); cell cycle proteins (e.g., cyclin
D1 and cyclin E); angiogenesis (e.g., vascular endothelial growth factor);
invasion (e.g., matrix metalloproteinases); antiapoptosis (e.g., bcl-2, bcl-XL,
XIAP, survivin, FLIP); and cellular proliferation (e.g., c-myc, AP-1, growth
factors). Numerous reports have suggested that Ayurvedic plants and their
components mediate their effects by modulating several of these recently
identified therapeutic targets. However, Ayurvedic medicine requires
rediscovery in light of our current knowledge of allopathic (modern) medicine.
The focus of this review is to elucidate the Ayurvedic concept of cancer,
including its classification, causes, pathogenesis and prevention; surgical
removal of tumours; herbal remedies; dietary modifications; and spiritual
treatments.
Keywords: apoptosis, Ayurvedic medicine, cancer, inflammation, metastasis
Expert Opin. Ther. Targets (2006) 10(1):87-118
PMID: 16441231
"From Ancient Medicine to Modern
Medicine: Ayurvedic Concepts of
Health and its role in Inflammation and Cancer"
J Soc Integr Oncol. 2007 Winter;5(1):25-37
Invited Review for the Journal of the Society for Integrative Oncology (winter
issue) Prachi Garodia, Haruyo Ichikawa, Nikita Malani, Gautam Sethi and Bharat
B Aggarwal?
Abstract
Recent statistics indicate that overall cancer incidence in the United States,
in spite of billions of dollars spent on research each year, has not changed
significantly in the last half century. Cancers of the prostate, breast, lung
and colon, while most common in the Western world, are least common in the
Eastern world. Allopathic medicine commonly practiced currently is only one
hundred years old. Although traditional medicine has been around for thousands
of years, no integration exists between it and allopathic medicine. Ayurveda,
the science of long life and one of the most ancient medical systems still
practiced on the Indian subcontinent, can be used in combination with modern
medicine to provide better treatment of cancer. This review focuses on the
Ayurvedic concept of the causes of cancer, its linkage with inflammation, its
diagnosis, prevention and treatment. How Ayurvedic medicine can be integrated
with allopathic medicine is also discussed in this review.
PMID: 17309811
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